Press Release
Aug 09, 2022
Contact: Chris Martin, IASLC Media Relations, cmartin@davidjamesgroup.com, 630.670.2745
(VIENNA, Austria — August 9, 2022 10:45 a.m. CEST) - About 53% of lung cancers in females are not attributable to smoking worldwide, and a new model presented today at the IASLC World Conference on Lung Cancer may allow clinicians the ability to assess and stratify lung cancer risk in female non-smokers in China.
Lanwei Guo, Henan Cancer Hospital, China examined data from 151,834 patients in Henan province, China, from October 2013 to October 2019 from the Cancer Screening Program in Urban China (CanSPUC).
The aim was to develop and validate a simple and non-invasive model which could assess and stratify lung cancer risk in female non-smokers in China.
Patients were randomly divided into the training (75,917) and validation (75,917) sets. Elder age, history of chronic respiratory disease, first-degree family history of lung cancer, menopause, and history of benign breast disease were the independent risk factors for lung cancer.
Using these five variables, Dr. Guo and colleagues platted one-year, three-year, and five-year lung cancer risk prediction nomograms. The area under the curve was 0.762, 0.718, and 0.703 for the one-, three- and five-year lung cancer risk in the training set, respectively. In the validation set, the model showed a good predictive discrimination, with the area under the curve was 0.646, 0.658, and 0.650 for the one-, three- and five-year lung cancer risk.
Related risk factors were identified through multivariable Cox regression analysis, followed by establishment of risk prediction nomogram. Discrimination [area under the curve (AUC)] and calibration were further performed to assess the validation of risk prediction nomogram in the training set, and then validated by the validation set.
“We developed and validated a simple and non-invasive lung cancer risk model in female non-smokers that can be applied to identify and triage patients at high risk for developing lung cancer in female non-smokers,” Dr. Guo reported.
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About the IASLC:
The International Association for the Study of Lung Cancer (IASLC) is the only global organization dedicated solely to the study of lung cancer and other thoracic malignancies. Founded in 1974, the association's membership includes nearly 7,500 lung cancer specialists across all disciplines in over 100 countries, forming a global network working together to conquer lung and thoracic cancers worldwide. The association also publishes the Journal of Thoracic Oncology, the primary educational and informational publication for topics relevant to the prevention, detection, diagnosis, and treatment of all thoracic malignancies. Visit www.iaslc.org for more information.
About the WCLC:
The WCLC is the world’s largest meeting dedicated to lung cancer and other thoracic malignancies, attracting more than 7,000 researchers, physicians and specialists from more than 100 countries. The goal is to increase awareness, collaboration and understanding of lung cancer, and to help participants implement the latest developments across the globe. The conference will cover a wide range of disciplines and unveil several research studies and clinical trial results. For more information, visit https://wclc2022.iaslc.org/